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1.

Embracing cancer complexity: Hallmarks of systemic disease.

Swanton, Charles; Bernard, Elsa; Abbosh, Chris; André, Fabrice; Auwerx, Johan; Balmain, Allan; Bar-Sagi, Dafna; Bernards, René; Bullman, Susan; DeGregori, James; Elliott, Catherine; Erez, Ayelet; Evan, Gerard; Febbraio, Mark A; Hidalgo, Andrés; Jamal-Hanjani, Mariam; Joyce, Johanna A; Kaiser, Matthew; Lamia, Katja; Locasale, Jason W; Loi, Sherene; Malanchi, Ilaria; Merad, Miriam; Musgrave, Kathryn; Patel, Ketan J; Quezada, Sergio; Wargo, Jennifer A; Weeraratna, Ashani; White, Eileen; Winkler, Frank; Wood, John N; Vousden, Karen H; Hanahan, Douglas.

Cell ; 187(7): 1589-1616, 2024 Mar 28.

Artículo en Inglés | MEDLINE | ID: mdl-38552609

2.

The next big questions in cancer research.

Loi, Sherene; Settleman, Jeffrey; Joyce, Johanna A; Pramesh, C S; Bernards, Rene; Fan, Jia; Merchant, Juanita L; Moslehi, Javid; Sellers, William R.

Cell ; 186(8): 1523-1527, 2023 04 13.

Artículo en Inglés | MEDLINE | ID: mdl-37059060

3.

An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential.

Wang, Liqin; Leite de Oliveira, Rodrigo; Huijberts, Sanne; Bosdriesz, Evert; Pencheva, Nora; Brunen, Diede; Bosma, Astrid; Song, Ji-Ying; Zevenhoven, John; Los-de Vries, G Tjitske; Horlings, Hugo; Nuijen, Bastiaan; Beijnen, Jos H; Schellens, Jan H M; Bernards, Rene.

Cell ; 173(6): 1413-1425.e14, 2018 05 31.

Artículo en Inglés | MEDLINE | ID: mdl-29754815

4.

How Much Longer Will We Put Up With $100,000 Cancer Drugs?

Workman, Paul; Draetta, Giulio F; Schellens, Jan H M; Bernards, René.

Cell ; 168(4): 579-583, 2017 02 09.

Artículo en Inglés | MEDLINE | ID: mdl-28187281

5.

A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility.

Vecchione, Loredana; Gambino, Valentina; Raaijmakers, Jonne; Schlicker, Andreas; Fumagalli, Arianna; Russo, Mariangela; Villanueva, Alberto; Beerling, Evelyne; Bartolini, Alice; Mollevi, David G; El-Murr, Nizar; Chiron, Marielle; Calvet, Loreley; Nicolazzi, Céline; Combeau, Cécile; Henry, Christophe; Simon, Iris M; Tian, Sun; in 't Veld, Sjors; D'ario, Giovanni; Mainardi, Sara; Beijersbergen, Roderick L; Lieftink, Cor; Linn, Sabine; Rumpf-Kienzl, Cornelia; Delorenzi, Mauro; Wessels, Lodewyk; Salazar, Ramon; Di Nicolantonio, Federica; Bardelli, Alberto; van Rheenen, Jacco; Medema, René H; Tejpar, Sabine; Bernards, René.

Cell ; 165(2): 317-30, 2016 Apr 07.

Artículo en Inglés | MEDLINE | ID: mdl-27058664

6.

A missing link in genotype-directed cancer therapy.

Bernards, René.

Cell ; 151(3): 465-8, 2012 Oct 26.

Artículo en Inglés | MEDLINE | ID: mdl-23101617

7.

MED12 controls the response to multiple cancer drugs through regulation of TGF-ß receptor signaling.

Huang, Sidong; Hölzel, Michael; Knijnenburg, Theo; Schlicker, Andreas; Roepman, Paul; McDermott, Ultan; Garnett, Mathew; Grernrum, Wipawadee; Sun, Chong; Prahallad, Anirudh; Groenendijk, Floris H; Mittempergher, Lorenza; Nijkamp, Wouter; Neefjes, Jacques; Salazar, Ramon; Ten Dijke, Peter; Uramoto, Hidetaka; Tanaka, Fumihiro; Beijersbergen, Roderick L; Wessels, Lodewyk F A; Bernards, René.

Cell ; 151(5): 937-50, 2012 Nov 21.

Artículo en Inglés | MEDLINE | ID: mdl-23178117

8.

EGFR activation limits the response of liver cancer to lenvatinib.

Jin, Haojie; Shi, Yaoping; Lv, Yuanyuan; Yuan, Shengxian; Ramirez, Christel F A; Lieftink, Cor; Wang, Liqin; Wang, Siying; Wang, Cun; Dias, Matheus Henrique; Jochems, Fleur; Yang, Yuan; Bosma, Astrid; Hijmans, E Marielle; de Groot, Marnix H P; Vegna, Serena; Cui, Dan; Zhou, Yangyang; Ling, Jing; Wang, Hui; Guo, Yuchen; Zheng, Xingling; Isima, Nikita; Wu, Haiqiu; Sun, Chong; Beijersbergen, Roderick L; Akkari, Leila; Zhou, Weiping; Zhai, Bo; Qin, Wenxin; Bernards, René.

Nature ; 595(7869): 730-734, 2021 07.

Artículo en Inglés | MEDLINE | ID: mdl-34290403

9.

Small-molecule inhibition of MAP2K4 is synergistic with RAS inhibitors in KRAS-mutant cancers.

Jansen, Robin A; Mainardi, Sara; Dias, Matheus Henrique; Bosma, Astrid; van Dijk, Emma; Selig, Roland; Albrecht, Wolfgang; Laufer, Stefan A; Zender, Lars; Bernards, René.

Proc Natl Acad Sci U S A ; 121(9): e2319492121, 2024 Feb 27.

Artículo en Inglés | MEDLINE | ID: mdl-38377196

10.

The phosphatase inhibitor LB-100 creates neoantigens in colon cancer cells through perturbation of mRNA splicing.

Dias, Matheus H; Liudkovska, Vladyslava; Montenegro Navarro, Jasmine; Giebel, Lisanne; Champagne, Julien; Papagianni, Chrysa; Bleijerveld, Onno B; Velds, Arno; Agami, Reuven; Bernards, René; Ciesla, Maciej.

EMBO Rep ; 2024 Apr 10.

Artículo en Inglés | MEDLINE | ID: mdl-38600345

11.

Dual Inhibition of CDK4/6 and XPO1 Induces Senescence With Acquired Vulnerability to CRBN-Based PROTAC Drugs.

Wang, Hui; Yuan, Shengxian; Zheng, Quan; Zhang, Sisi; Zhang, Qianqian; Ji, Shuyi; Wang, Wei; Cao, Ying; Guo, Yuchen; Yang, Xupeng; Geng, Haigang; Yang, Fan; Xi, Shuijun; Jin, Guangzhi; Zhang, Jianming; Gao, Qiang; Bernards, René; Qin, Wenxin; Wang, Cun.

Gastroenterology ; 2024 Jan 21.

Artículo en Inglés | MEDLINE | ID: mdl-38262581

12.

It's diagnostics, stupid.

Bernards, René.

Cell ; 141(1): 13-7, 2010 Apr 02.

Artículo en Inglés | MEDLINE | ID: mdl-20371338

13.

Radical Sabbaticals.

Clevers, Hans; Firestein, Stuart; Ringrose, Leonie; Bernards, Rene; Darwin, K Heran; Vance, Russell E.

Cell ; 163(4): 788-9, 2015 Nov 05.

Artículo en Inglés | MEDLINE | ID: mdl-26544929

14.

NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome.

Hölzel, Michael; Huang, Sidong; Koster, Jan; Ora, Ingrid; Lakeman, Arjan; Caron, Huib; Nijkamp, Wouter; Xie, Jing; Callens, Tom; Asgharzadeh, Shahab; Seeger, Robert C; Messiaen, Ludwine; Versteeg, Rogier; Bernards, René.

Cell ; 142(2): 218-29, 2010 Jul 23.

Artículo en Inglés | MEDLINE | ID: mdl-20655465

15.

Inducing and exploiting vulnerabilities for the treatment of liver cancer.

Wang, Cun; Vegna, Serena; Jin, Haojie; Benedict, Bente; Lieftink, Cor; Ramirez, Christel; de Oliveira, Rodrigo Leite; Morris, Ben; Gadiot, Jules; Wang, Wei; du Chatinier, Aimée; Wang, Liqin; Gao, Dongmei; Evers, Bastiaan; Jin, Guangzhi; Xue, Zheng; Schepers, Arnout; Jochems, Fleur; Sanchez, Antonio Mulero; Mainardi, Sara; Te Riele, Hein; Beijersbergen, Roderick L; Qin, Wenxin; Akkari, Leila; Bernards, René.

Nature ; 574(7777): 268-272, 2019 10.

Artículo en Inglés | MEDLINE | ID: mdl-31578521

16.

Proinflammatory activity of VEGF-targeted treatment through reversal of tumor endothelial cell anergy.

Nowak-Sliwinska, Patrycja; van Beijnum, Judy R; Griffioen, Christian J; Huinen, Zowi R; Sopesens, Nadine Grima; Schulz, Ralph; Jenkins, Samir V; Dings, Ruud P M; Groenendijk, Floris H; Huijbers, Elisabeth J M; Thijssen, Victor L J L; Jonasch, Eric; Vyth-Dreese, Florry A; Jordanova, Ekaterina S; Bex, Axel; Bernards, René; de Gruijl, Tanja D; Griffioen, Arjan W.

Angiogenesis ; 26(2): 279-293, 2023 05.

Artículo en Inglés | MEDLINE | ID: mdl-36459240

17.

RNAi Delivers Insights into Liver Cancer.

Bernards, René.

Cell ; 135(5): 793-5, 2008 Nov 28.

Artículo en Inglés | MEDLINE | ID: mdl-19041743

18.

Mutational profiles associated with resistance in patients with BRAFV600E mutant colorectal cancer treated with cetuximab and encorafenib +/- binimetinib or alpelisib.

Huijberts, Sanne C F A; Boelens, Mirjam C; Bernards, Rene; Opdam, Frans L.

Br J Cancer ; 124(1): 176-182, 2021 01.

Artículo en Inglés | MEDLINE | ID: mdl-33204026

19.

Phase I Study of Afatinib and Selumetinib in Patients with KRAS-Mutated Colorectal, Non-Small Cell Lung, and Pancreatic Cancer.

van Brummelen, Emilie M J; Huijberts, Sanne; van Herpen, Carla; Desar, Ingrid; Opdam, Frans; van Geel, Robin; Marchetti, Serena; Steeghs, Neeltje; Monkhorst, Kim; Thijssen, Bas; Rosing, Hilde; Huitema, Alwin; Beijnen, Jos; Bernards, Rene; Schellens, Jan.

Oncologist ; 26(4): 290-e545, 2021 04.

Artículo en Inglés | MEDLINE | ID: mdl-33296125

20.

CDK12 inhibition mediates DNA damage and is synergistic with sorafenib treatment in hepatocellular carcinoma.

Wang, Cun; Wang, Hui; Lieftink, Cor; du Chatinier, Aimee; Gao, Dongmei; Jin, Guangzhi; Jin, Haojie; Beijersbergen, Roderick L; Qin, Wenxin; Bernards, René.

Gut ; 69(4): 727-736, 2020 04.

Artículo en Inglés | MEDLINE | ID: mdl-31519701

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Embracing cancer complexity: Hallmarks of systemic disease.

The next big questions in cancer research.

An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential.

How Much Longer Will We Put Up With $100,000 Cancer Drugs?

A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility.

A missing link in genotype-directed cancer therapy.

MED12 controls the response to multiple cancer drugs through regulation of TGF-ß receptor signaling.

EGFR activation limits the response of liver cancer to lenvatinib.

Small-molecule inhibition of MAP2K4 is synergistic with RAS inhibitors in KRAS-mutant cancers.

The phosphatase inhibitor LB-100 creates neoantigens in colon cancer cells through perturbation of mRNA splicing.

Dual Inhibition of CDK4/6 and XPO1 Induces Senescence With Acquired Vulnerability to CRBN-Based PROTAC Drugs.

It's diagnostics, stupid.

Radical Sabbaticals.

NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome.

Inducing and exploiting vulnerabilities for the treatment of liver cancer.

Proinflammatory activity of VEGF-targeted treatment through reversal of tumor endothelial cell anergy.

RNAi Delivers Insights into Liver Cancer.

Mutational profiles associated with resistance in patients with BRAFV600E mutant colorectal cancer treated with cetuximab and encorafenib +/- binimetinib or alpelisib.

Phase I Study of Afatinib and Selumetinib in Patients with KRAS-Mutated Colorectal, Non-Small Cell Lung, and Pancreatic Cancer.

CDK12 inhibition mediates DNA damage and is synergistic with sorafenib treatment in hepatocellular carcinoma.